Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation
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- 作者：Qian Zhao ; Jing Hou ; Bo Chen ; Xue Shao ; Ruiming Zhu ; Qian Bu ; Hui Gu ; Yan Li ; Baolai Zhang ; Changman Du ; Dengqi Fu ; Jueying Kong ; Li Luo ; Hailei Long ; Hongyu Li ; Yi Deng ; Yinglan Zhao ; Xiaobo Cen ; xbcen@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Prenatal cocaine exposure ; IGF-II ; Cognitive function ; DNA methylation ; DNMTs ; l-Methionine ; CaMKIIα
- 刊名：Neurobiology of Disease
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：82
- 期：Complete
- 页码：54-65
- 全文大小：2294 K
文摘
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PCOC impaired spatial learning and memory and increased anxiety in the offspring.
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PCOC decreased the expression of hippocampal IGF-II in the offspring.
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PCOC increased hippocampal DNA methylation level of Igf-II in the offspring.
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Hippocampal IGF-II injection reversed the cognitive deficits in PCOC offspring.
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Exogenous IGF-II administration reactivates hippocampal CaMKIIα signaling.