Comparative proteomic identification of the hepatopancreas response to cold stress in white shrimp, Litopenaeus vannamei
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A reliable hepatopancreas protein extraction method was established.

81.93% of the total hepatopancreas proteins were distributed in the range of pI 4–7.

37 proteins exhibited significant alterations upon cold stress.

Cold stress may lead to the decline of innate immunity of the shrimp.

The anabolism is vigorous in the hepatopancreas under cold stress.

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