Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-β production
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- 作者：Jingyi Luoa ; b ; Liurong Fanga ; b ; Nan Donga ; b ; Puxian Fanga ; b ; Zhen Dinga ; b ; Dang Wanga ; b ; Huanchun Chena ; b ; Shaobo Xiaoa ; b ; vet@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Porcine deltacoronavirus (PDCoV) ; Interferon ; RIG-I Signaling pathway
- 刊名：Virology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：495
- 期：Complete
- 页码：10-17
- 全文大小：3556 K
文摘
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PDCoV infection fails to induce IFN-β production in LLC-PK1 cells.
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PDCoV infection suppresses Sendai virus-or poly(I: C)-induced IFN-β production.
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PDCoV impedes Sendai virus- or poly(I: C)-induced activation of NF-κB and IRF3.
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PDCoV interrupts RIG-I signaling pathway to inhibit IFN-β production.