Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination
详细信息 查看全文
- 作者：Shengfeng Huang1 ; 8 ; Xin Tao1 ; 8 ; Shaochun Yuan1 ; 8 ; Yuhang Zhang3 ; Peiyi Li1 ; Helen A. Beilinson3 ; Ya Zhang1 ; Wenjuan Yu1 ; Pierre Pontarotti5 ; Hector Escriva6 ; Yann Le Petillon6 ; Xiaolong Liu7 ; Shangwu Chen1 ; David G. Schatz3 ; 4 ; Anlong Xu1 ; 2 ; lssxal@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：30 June 2016
- 年：2016
- 卷：166
- 期：1
- 页码：102-114
- 全文大小：5803 K
文摘
- listitem" id="list_ulist0010">
- •
A new cut-and-paste DNA transposon called ProtoRAG has been discovered in lancelets
- •
It has the structural features expected for the hypothetical RAG transposon
- •
It is capable of TIR-dependent DNA cleavage, transposition, and self-resealing
- •
It hence represents a molecular “living fossil” of the long-sought RAG transposon