Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis via inhibiting the activation of NF-κB signaling pathway
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- 作者：Shaogui Wang1 ; Zhiying Yang1 ; Fengxiao Xiong1 ; Cheng Chen ; Xiaojuan Chao ; Junying Huang ; Heqing Huang ; huangheq@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diabetic nephropathy ; Betulinic acid ; NF-κB ; Fibronectin
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：434
- 期：Complete
- 页码：135-143
- 全文大小：1950 K
文摘
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Betulinic acid ameliorated diabetic nephropathy in the streptozocin-induced diabetic rats.
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Betulinic acid suppressed the expression of fibronectin in both diabetic rat kidneys and high glucose-treated GMCs.
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Betulinic acid blocked high glucose-induced NF-κB activity.