Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder
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- 作者：Xin-hua Yanga ; b ; Jia Huangc ; Yong Lanb ; Cui-ying Zhub ; Xiao-qun Liud ; Ye-fei Wanga ; Eric F.C. Cheunge ; Guang-rong Xiea ; xiegr2000@126.com" class="auth_mail" title="E-mail the corresponding author ; Raymond C.K. Chanc ; rckchan@psych.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACC ; anterior cingulate cortex ; BDI ; Beck Depression Inventory ; DA ; dopamine ; DSM-IV ; Diagnostic and Statistical Manual of Mental Disorders IV ; EEfRT ; Effort-Expenditure for Rewards Task ; EPI ; echoplanar imaging ; GEE ; Generalized Estimating Equation ; HAMD ; Hamilton Rating Scale for Depression ; HC/HR ; high cost/high reward ; LC/LR ; low cost/low reward ; MDD ; major depressive disorder ; PFC ; medial prefrontal cortex ; SCID-NP ; Structured Clinical Interview for DSM ; Non-patients ; SHAPS ; Snaith&ndash ; Ha
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：52-59
- 全文大小：480 K
文摘
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Examine the neural mechanism of reward-related decision-making in MDD patients
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MDD patients showed reduced caudate nucleus and superior temporal gyrus activation
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Abnormal decision-making reflected in cortico-striatal connectivity deactivation