Utility of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine. An efficient solid-phase synthesis of olomoucine

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• 作者：Hammarströ ; m ; Lars G. J. ; Smith ; David B. ; Talamá ; s ; Francisco X. ; Labadie ; Sharada S. ; et. al.
• 刊名：Tetrahedron Letters
• 出版年：2002
• 出版时间：November 4, 2002
• 年：2002
• 卷：43
• 期：45
• 页码：8071-8073
• 全文大小：232 K

文摘

4,6-Dichloro-2-(methylthio)-5-nitropyrimidine has been utilized as a building block for an efficient nine-step synthesis of olomoucine. The methodology reported herein is applicable to the regiocontrolled solution and solid-phase synthesis of libraries of highly substituted purines, as well as other related scaffolds.