Ulmosides A and B: Flavonoid 6-C-glycosides from Ulmus

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• 作者：Preeti Rawat ; Manmeet Kumar ; Kunal Sharan ; Naibedya Chattopadhyay ; Rakesh Maurya
• 关键词：Ulmus wallichiana ; Flavonoid-6-C-glycosides ; Osteogenic ; Osteoblast ; Differentiation
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2009
• 出版时间：15 August 2009
• 年：2009
• 卷：19
• 期：16
• 页码：4684-4687
• 全文大小：221 K

文摘

Chemical investigation of Ulmus wallichiana stem bark resulted in isolation and identification of three new compounds (2S,3S)-(+)-3′,4′,5,7-tetrahydroxydihydroflavonol-6-C-β-d-glucopyranoside (1), (2S,3S)-(+)-4′,5,7-trihydroxydihydroflavonol-6-C-β-d-glucopyranoside (3) and 3-C-β-d-glucopyranoside-2,4,6-trihydroxymethylbenzoate (8), together with five known flavonoid-6-C-glucosides (2, 4–7). Their structures were elucidated using 1D and 2D NMR spectroscopic analysis. The absolute stereochemistry in compounds 1 and 3 were established with the help of CD data analysis and comparison with the literature data analysis. All the isolated compounds (1–8) were assessed for promoting the osteoblast differentiation using primary culture of rat osteoblast as an in vitro system. Compounds 1–3 and 5 significantly increased osteoblast differentiation as assessed by alkaline phosphatase activity.