Synthesis of two-photon active cinnamoyl coumarins for high-contrast imaging of cancer cells and their photophysical characterization

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• 作者：Preeti Yadav^a ; ¹ ; Soumitra Satapathi^b ; ¹ ; Meena Kumari^a ; Akanksha Chaturvedi^c ; Lian Li^d ; Lynne A. Samuelson^d ; Jayant Kumar^b ; ^{jayant_kumar@uml.edu" class="auth_mail} ; Sunil K. Sharma^a ; ^{sk.sharma90@gmail.com" class="auth_mail}
• 关键词：Two-photon active ; 4-Dimethylaminocinnamoyl coumarins ; Stokes shift ; Label
• 刊名：Journal of Photochemistry and Photobiology A: Chemistry
• 出版年：15 April, 2014
• 年：2014
• 卷：280
• 期：Complete
• 页码：39-45
• 全文大小：610 K

文摘

A series of two-photon (TP) active 4-dimethylaminocinnamoyl coumarins were synthesized. These compounds exhibit red shift in absorption and considerable Stokes shift in emission spectra in comparison to the parent coumarin. Large TP absorption cross-sections were measured for all the coumarins in dilute solutions. A correlation between the chemical structure and TP characteristics was established. TP confocal microscopy revealed that these coumarin derivatives can be internalized by cancer cells rendering them a potential candidate as a label in TP confocal imaging.