文摘
A cohort of 5527 patients had an increasing trend for hypervitaminosis D [25-hydroxyvitamin D (25-OHD) >250 nmol/L] from 2011 to 2016 (1.48% to 7.82%). Of patients with hypervitaminosis D and vitamin D intoxication (25-OHD>375 nmol/L), 46.22% and 62.25%, respectively, had elevated calcium or suppressed parathyroid hormone. Children, women, and surgical patients are especially susceptible to hypervitaminosis D, There has been a global secular trend of increase in 25-OHD over the past number of years and a disturbing trend of increased hypervitaminosis D in the developing world. Empiric, unmonitored, prolonged vitamin D supplementation, especially intramuscular, should be discouraged.