The increasing problem of subclinical and overt hypervitaminosis D in India: An institutional experience and review

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• 作者：Lokesh Kumar Sharma ; M.D.p>ap> ; Deep Dutta ; M.D. ; D.M. ; M.R.C.P. ; F.A.C.E.p>bp>p> ; p>p>deepdutta2000@yajoo.comp> ; Neera Sharma ; M.D.p>ap> ; Adesh Kisanji Gadpayle ; M.D.p>cp>
• 关键词：Vitamin D ; Toxicity ; Intoxication ; Hypervitaminosis ; Deficiency
• 刊名：Nutrition
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：34
• 期：Complete
• 页码：76-81
• 全文大小：240 K
• 卷排序：34

文摘

A cohort of 5527 patients had an increasing trend for hypervitaminosis D [25-hydroxyvitamin D (25-OHD) >250 nmol/L] from 2011 to 2016 (1.48% to 7.82%). Of patients with hypervitaminosis D and vitamin D intoxication (25-OHD>375 nmol/L), 46.22% and 62.25%, respectively, had elevated calcium or suppressed parathyroid hormone. Children, women, and surgical patients are especially susceptible to hypervitaminosis D, There has been a global secular trend of increase in 25-OHD over the past number of years and a disturbing trend of increased hypervitaminosis D in the developing world. Empiric, unmonitored, prolonged vitamin D supplementation, especially intramuscular, should be discouraged.