17-hydroxyprogesterone blunts the hypertensive response associated with reductions in uterine perfusion pressure in pregnant rats
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- 作者：Edward W. Veillon Jr ; Sharon D. Keiser ; Marc R. Parrish ; William Bennett ; Kathy Cockrell ; Lillian F. Ray ; Joey P. Granger ; James N. Martin Jr ; Babbette LaMarca
- 关键词：endothelin ; 17-hydroxyprogesterone caproate ; hypertension ; preeclampsia ; reduced uterine perfusion
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：2009
- 出版时间：September 2009
- 年：2009
- 卷：201
- 期：3
- 页码：324.e1-324.e6
- 全文大小：495 K
文摘
Objective
Reduction in uteroplacental perfusion (RUPP) in pregnant rats is associated with hypertension, elevated cytokines, and activation of the endothelin (ET-1) system. Our objective was to determine whether the antiinflammatory properties of 17-alpha-hydroxyprogesterone caproate (17 OHP) reduce cytokine-stimulated vasoactive pathways that are associated with hypertension in response to placental ischemia.Study Design
Mean arterial pressure (MAP), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and renal ET-1 were measured in the following: pregnant controls, pregnant controls plus 17 OHP (6.6 mg/kg), RUPP rats, and RUPP rats plus 17 OHP.
Results
MAP increased 29 mm Hg in RUPP rats compared with pregnant controls (P < .001), whereas in RUPP plus 17 OHP rats, MAP increased only 19 mm Hg (P < .05). TNF-α and IL-6 increased 2- to 3-fold, respectively, in response to placental ischemia but was normalized in RUPP rats treated with 17 OHP. ET-1 increased 3-fold in RUPP rats but was markedly less in RUPP plus 17 OHP rats.
Conclusion
17 OHP blunts hypertension associated with RUPP, possibly via suppression of cytokine-stimulated ET-1 activation.