Improved efficacy of cisplatin in combination with a nano-formulation of pentacyclic triterpenediol
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- 作者：Noor Alamb ; Arem Qayuma ; c ; Ashok Kumara ; c ; Vaibhav Khareb ; Parduman Raj Sharmac ; Samar Singh Andotrad ; Shashank K. Singha ; c ; Surinder Kould ; skoul@iiim.ac.in" class="auth_mail" title="E-mail the corresponding author ; Prem N. Guptaa ; b ; pngupta10@gmail.com" class="auth_mail" title="E-mail the corresponding author ; pngupta@iiim.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cisplatin ; Boswellia serrata ; Drug combination ; PLGA ; Nanoparticles
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：109-116
- 全文大小：973 K
文摘
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TPD nanoparticles showed a time dependent increase in cellular uptake efficiency.
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TPD nanoparticles showed synergistic interaction between cisplatin.
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The dose of cisplatin was reduced to 3.8 folds using this combination.
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This combination could be potential in order to reduce does limiting toxicities of cisplatin.