Dual-modality drainage of infected and symptomatic walled-off pancreatic necrosis: long-term clinical outcomes

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• 作者：Andrew S. Ross ; MD ; Shayan Irani ; MD ; S. Ian Gan ; MD ; Flavio Rocha ; MD ; Justin Siegal ; MD ; Mehran Fotoohi ; MD ; Ellen Hauptmann ; MD ; David Robinson ; MD ; Robert Crane ; MD ; Richard Kozarek ; MD ; Michael Gluck ; MD
• 关键词：DMD ; dual-modality drainage ; PCF ; pancreaticocutaneous fistula ; PFC ; pancreatic fluid collection ; WOPN ; walled-off pancreatic necrosis
• 刊名：Gastrointestinal Endoscopy
• 出版年：June 2014
• 年：2014
• 卷：79
• 期：6
• 页码：929-935
• 全文大小：543 K

文摘

Management options for symptomatic and infected walled-off pancreatic necrosis (WOPN) have evolved over the past decade from open surgical necrosectomy to more minimally invasive approaches. We reported the use of a combined percutaneous and endoscopic approach (dual modality drainage [DMD]) for the treatment of symptomatic and infected WOPN, with good short-term outcomes in a small cohort of patients.

Objective

To describe the long-term outcomes of 117 patients with symptomatic and infected WOPN treated by DMD.

Design

Review of a prospective, internal review board–approved database.

Setting

Single, North American, tertiary-care center.

Patients

All patients with symptomatic and infected WOPN treated by DMD at our institution between 2007 and 2012.

Intervention

DMD of symptomatic and infected WOPN.

Main Outcome Measurements

Disease-related mortality, pancreaticocutaneous fistula formation, need for early and late surgical intervention, procedure-related adverse events.

Results

A total of 117 patients underwent DMD for symptomatic and infected WOPN. A total of 103 have completed treatment, with all percutaneous drains removed. Ten patients are still undergoing treatment, and 4 patients died with percutaneous drains in place (3.4% disease-related mortality). For the patients completing therapy, the median duration of follow-up was 749.5 days. No patients required surgical necrosectomy or surgical treatment of DMD-related adverse events; 3 patients required late surgery for pain (n = 2) and gastric outlet obstruction (n = 1). There were no procedure-related deaths. In patients who have completed treatment, percutaneous drains have been removed in 100%; no patients have developed pancreaticocutaneous fistulas.

Limitations

Single-center design, lack of a comparison group.

Conclusion

DMD for symptomatic and infected WOPN results in favorable clinical outcomes; complete avoidance of pancreaticocutaneous fistulae, surgical necrosectomy, and major procedure-related adverse events, while maintaining single-digit disease-related mortality.