Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis
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- 作者：Simran J. Kaura ; simran.arora0905@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Stephanie R. McKeownb ; sr.mckeown@ulster.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Shazia Rashida ; srashid@amity.edu" class="auth_mail" title="E-mail the corresponding author ; shaziarashid123@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAV ; Adeno-associated viruses ; ATP ; Adenosine Triphosphate ; ALS-FTD ; ALS combined with frontotemporal dementia ; ALS ; Amyotrophic lateral sclerosis ; ALSoD ; Amyotrophic lateral sclerosis online database ; C9orf72 ; Chromosome 9 open reading frame 72 ; ERGIC ; Endoplasmic Reticulum-Golgi intermediate compartment ; FUS ; Fused in sarcoma/translocated in sarcoma ; H2O2 ; Hydrogen peroxide ; LMNs ; Lower motor neurons ; mRNA ; Messenger ribonucleic acid ; RXR ; Retinoid X receptor ; O2 ; Oxygen ; O2&minus ; ; Supe
- 刊名：Gene
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：577
- 期：2
- 页码：109-118
- 全文大小：1567 K
文摘
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Introduction about amyotrophic lateral sclerosis (ALS)
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Epidemiology of ALS at global level
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Genes involved in the pathogenesis of ALS
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Role of SOD 1 and its mutations in ALS
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Diagnosis, management and future therapies