A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines

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• 作者：Rasool Khan ; Mohammad Arfan ; Javeed Mahmood ; Shazia Anjum ; M. Iqbal Choudhary
• 关键词：3-Amino-2-phenyl-4(3H)-quinazolinone ; Triethylorthoacetate ; Unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines
• 刊名：Chinese Chemical Letters
• 出版年：2010
• 出版时间：August 2010
• 年：2010
• 卷：21
• 期：8
• 页码：905-910
• 全文大小：169 K

文摘

A series of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines was synthesized by reacting ethyl(1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)ethanimidoate (2) and suitable reactive aromatic amines. Structures’ determination of the synthesized compounds was carried out using spectroscopic techniques including IR, ¹H NMR, and mass spectrometry. Structural effects on reactivity were also studied.