Photosensitive controlled release with polyethylene glycol–anthracene modified alginate

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• 作者：L.A. Wells ; H. Sheardown  ; ;   ; ^{sheardow@mcmaster.ca}
• 关键词：Alginate ; Photoresponsive ; Anthracene ; Drug delivery ; Smart biomaterials
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：79
• 期：2
• 页码：304-313
• 全文大小：409 K
• ISSN：S093964111100124X

文摘

Covalent modification of alginate with polyethylene glycol–conjugated anthracene molecules has the potential to both stabilize the alginate and act as a photosensitive crosslinker. Release studies with Coomassie Blue show lengthy release times from the alginate photogels that extend past 70 days with, for example, 17% versus 27% release at 1750 h (73 days) for photogels with and without 365-nm UV light treatment for 30 min at 10 mW/cm² in the initial release period. Photocrosslinking of the photogels after loading effectively “locks?in drug compounds to control their release. Effective crosslinking densities and controls of polyethylene glycol-crosslinked alginate and physically crosslinked calcium alginate gels suggest strong interactions between Coomassie Blue and both alginate and anthracene. Photogels containing anthracene-capped star-polyethylene glycol show increased photosensitivity with modified release profiles. Ultimately, the covalent modification of alginate with photoactive crosslinkers has the potential to produce a long-term, photosensitive, controlled release system.