Impact of bilateral anterior cingulotomy on neurocognitive function in patients with intractable pain

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• 作者：Chun-Po Yen ; Chu-Yun Kuan ; Jason Sheehan ; Sui-Sum Kung ; Chin-Chui Wang ; Ching-Kuan Liu ; Aij Lie Kwan
• 关键词：Cancer ; Cingulate cortex ; Cingulotomy ; Cognitive function ; Pain
• 刊名：Journal of Clinical Neuroscience
• 出版年：2009
• 出版时间：February 2009
• 年：2009
• 卷：16
• 期：2
• 页码：214-219
• 全文大小：249 K

文摘

Although the cingulate cortices are important with regard to neurocognitive functions, outcome studies usually fail to identify evident cognitive dysfunction following anterior cingulotomy. The aim of this study was to document any impairment of neurocognitive functions following anterior cingulotomy. Between September 2002 and April 2004, 10 patients underwent stereotactic bilateral anterior cingulotomy for intractable cancer pain. A neuropsychological assessment of each patient was performed 1 day prior to surgery and 1 week and 1 month post-operatively. Assessment of pain relief was evaluated with a short form of the McGill pain questionnaire. Six of the 10 patients achieved fair to good pain relief following the cingulotomy procedure. Most neurocognitive functions, including language, memory, motor, visual-constructional, and intellectual functions, remained unaffected. A decline in focused attention performance was identified at the early post-operative assessment. The results of this longitudinal evaluation will help to better define the risk-to-benefit profile of cingulotomy for intractable pain.