MicroRNA: A new therapeutic strategy for cardiovascular diseases

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• 作者：Saheli Samanta ; PhD^a ; Sathyamoorthy Balasubramanian ; PhD^a ; ^b ; Sheeja Rajasingh ; MSc ; MPhil^a ; Urmi Patel ; BS^a ; Anuradha Dhanasekaran ; PhD^b ; Buddhadeb Dawn ; MD^a ; Johnson Rajasingh ; MPhil ; PhD^a ; ^c ; ^{rjohnson9@kumc.edu" class="auth_mail" title="E-mail the corresponding author} ; ^{singhraja55@hotmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：MicroRNAs ; Endothelial cells ; Cardiac fibrosis ; Atherosclerosis ; Myocardial infarction ; Stroke ; Hypertension
• 刊名：Trends in Cardiovascular Medicine
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：26
• 期：5
• 页码：407-419
• 全文大小：1667 K

文摘

Myocardial infarction, atherosclerosis, and hypertension are the most common heart-related diseases that affect both the heart and the blood vessels. Multiple independent risk factors have been shown to be responsible for cardiovascular diseases. The combination of a healthy diet, exercise, and smoking cessation keeps these risk factors in check and helps maintain homeostasis. The dynamic monolayer endothelial cell integrity and cell–cell communication are the fundamental mechanisms in maintaining homeostasis. Recently, it has been revealed that small noncoding RNAs (ncRNAs) play a critical role in regulation of genes involved in either posttranscriptional or pretranslational modifications. They also control diverse biological functions like development, differentiation, growth, and metabolism. Among ncRNAs, the short interfering RNAs (siRNAs), and microRNAs (miRNAs) have been extensively studied, but their specific functions remain largely unknown. In recent years, miRNAs are efficiently studied as one of the important candidates for involvement in most biological processes and have been implicated in many human diseases. Thus, the identification and the respective targets of miRNAs may provide novel molecular insight and new therapeutic strategies to treat diseases. This review summarizes the recent developments and insight on the role of miRNAs in cardiovascular disease prognosis, diagnostic and clinical applications.