Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa

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• 作者：Atta-ur-Rahman ; Parveen ; Shehnaz ; Khalid ; Asaad ; Farooq ; Afgan ; Choudhary ; M. Iqbal
• 关键词：Buxus papillosa ; Buxaceae ; Triterpenoid alkaloids ; Buxakashmiramine ; Buxakarachiamine ; Buxahejramine ; Anticholinesterase activity
• 刊名：Phytochemistry
• 出版年：2001
• 出版时间：November, 2001
• 年：2001
• 卷：58
• 期：6
• 页码：963-968
• 全文大小：141 K

文摘

Three triterpenoid alkaloids, buxakashmiramine [(20S)-20-dimethylamino-4′,6′-dimethoxy-5′-hydroxybenzoylamino-3β-methyl-buxan-31-ol] (</cross-ref>), buxakarachiamine [(20S)-20-dimethylamino-2′-hydroxy-3β-methyl-3′-methyl-butanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] () and buxahejramine [(20S)-20-dimethylamino-2′-hydroxy-3β-methyl-3′-methyl-pentanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] (3) were isolated from the leaves of Buxus papillosa. Four known bases, cycloprotobuxine-C (4), cyclovirobuxeine-A (5), cyclomicrophylline-A (6) and semperviraminol (7) were isolated for the first time from this species. Their structures were established through extensive spectroscopic studies. Most of these compounds exhibited anticholinesterase activity.