Oxytocin and catechol-O-methyltransferase receptor genotype predict the length of the first stage of labor

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• 作者：Abdullah S. Terkawi ; MD^a ; William M. Jackson ; MD^c ; Mari-Paule Thiet ; MD^d ; Shehnaz Hansoti ; MD^b ; Rabeena Tabassum ; MD^b ; Pamela Flood ; MD^e
• 关键词：COMT ; genetic ; labor ; mathematic model ; oxytocin receptor ; polymorphism
• 刊名：American Journal of Obstetrics and Gynecology
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：207
• 期：3
• 页码：184.e1-184.e8
• 全文大小：677 K

文摘

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Objective

We aimed to identify genetic factors that influence the rate of the first stage of labor.

Study Design

We prospectively enrolled 233 laboring nulliparous parturients. Demographic, clinical, and genetic data were collected. We evaluated the influence of population and individual variability using a nonlinear mixed effects model.

Results

Parturients who were homozygous for ¡°G¡± at oxytocin receptor gene rs53576 transitioned to active labor later and thus had slower labor. Catechol-O-methyltransferase rs4633 genotype TT was associated with slower latent phase labor. Labor induction with prostaglandin was associated with faster labor, and request for meperidine was associated with slower labor. Birthweight was related inversely to the rate of the active phase.

Conclusion

There are demographic, clinical, and genetic factors that influence an individual's rate of labor progress. This information could be used in automated form to improve the prediction of the length of the first stage of labor.