MicroRNA-related polymorphisms and non-Hodgkin lymphoma susceptibility in the Multicenter AIDS Cohort Study

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• 作者：Erin C. Peckham-Gregory ; Ph.D. M.P.H.^a ; ^{Erin.Peckham@bcm.edu} ; Dharma R. Thapa^b ; Jeremy Martinson^c ; Priya Duggal^d ; Sudhir Penugonda^e ; Jay H. Bream^f ; Po-Yin Chang^a ; Sugandha Dandekar^g ; Shen-Chih Chang^a ; Roger Detels^a ; Otoniel Martí ; nez-Maza^a ; ^b ; ^h ; ⁱ ; Zuo-Feng Zhang^a ; Shehnaz K. Hussain^a ; ^j
• 关键词：miRNA ; MicroRNA ; miRNA-SNPs ; MicroRNA-related polymorphisms ; AIDS-NHL ; AIDS-associated non-Hodgkin lymphoma ; MACS ; Multicenter AIDS Cohort Study ; EBV ; Epstein-Barr virus ; SNPs ; single nucleotide polymorphisms ; OR ; adjusted odds ratios ; CIs ; confidence intervals ; CNS ; central nervous system ; SB ; semi-Bayes ; NHW ; non-Hispanic Whites ; MR ; adjusted mean ratios ; NHL ; non-Hodgkin lymphoma ; UTR ; untranslated region ; MAF ; minor allele frequency ; HWE ; Hardy-Weinberg equilibrium ; LD ; linkage disequilibriu
• 刊名：Cancer Epidemiology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：45
• 期：Complete
• 页码：47-57
• 全文大小：507 K
• 卷排序：45

文摘

This study generated data on novel miRNA-related susceptibility loci for AIDS-NHL. DDX20 rs197412 in a miRNA biogenesis gene increases AIDS-NHL risk and miRNA serum levels. HIF1A rs2057482 creates a miRNA-196a2 binding site and influences AIDS-NHL risk. These results suggest biomarkers and miRNA pathways for AIDS-NHL risk stratification.