Interleukin-26: An IL-10-related cytokine produced by Th17 cells

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• 作者：Raymond P. Donnelly ; Faruk Sheikh ; Harold Dickensheets ; Ram Savan ; Howard A. Young ; Mark R. Walter
• 关键词：IL-26 ; Th17 cells ; IL-20R1 ; STAT3 ; Inflammation
• 刊名：Cytokine and Growth Factor Reviews
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：21
• 期：5
• 页码：393-401
• 全文大小：536 K

文摘

IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-γ) and IL22 (IL-22). IL-26 is often co-expressed with IL-22 by activated T cells, especially Th17 cells. It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains. IL-26 receptors are primarily expressed on non-hematopoietic cell types, particularly epithelial cells. Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes. The biological functions of IL-26 have only begun to be defined.