Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury
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- 作者：Aurelie Rouxa ; Ludovic Mullera ; Shelley N Jacksona ; Jeremy Posta ; Katherine Baldwina ; Barry Hoffere ; Carey D Balaband ; Damon Barbaccic ; J. Albert Schultzc ; Shawn Goutyb ; Brian M Coxb ; Amina S. Woodsa ; awoods@intra.nida.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Traumatic brain injury ; Controlled cortical impact ; Mass spectrometry imaging ; Silver nanoparticles implantation ; Lipids
- 刊名：Journal of Neuroscience Methods
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：272
- 期：Complete
- 页码：19-32
- 全文大小：5390 K
文摘
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MSI allows the in situ mapping of molecules directly from tissues.
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Brain images showed changes in most lipids classes 3 days after TBI.
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Signaling lipids such as increase in ceramides increased as early as 1 day after the injury.
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More diffuse lipid changes are observed outside of the injured area.
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Ceramides, diacylglycerols and cholesteryl esters are good biomarkers for TBI.