Oxidative bioelectrocatalysis: From natural metabolic pathways to synthetic metabolons and minimal enzyme cascades

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• 作者：Shelley D. Minteer ^{minteer@chem.utah.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Metabolic pathway ; Bioelectrocatalysis ; Metabolon ; Enzyme cascade ; Biofuel cell
• 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：1857
• 期：5
• 页码：621-624
• 全文大小：368 K

文摘

Anodic bioelectrodes for biofuel cells are more complex than cathodic bioelectrodes for biofuel cells, because laccase and bilirubin oxidase can individually catalyze four electron reduction of oxygen to water, whereas most anodic enzymes only do a single two electron oxidation of a complex fuel (i.e. glucose oxidase oxidizing glucose to gluconolactone while generating 2 electrons of the total 24 electrons), so enzyme cascades are typically needed for complete oxidation of the fuel. This review article will discuss the lessons learned from natural metabolic pathways about multi-step oxidation and how those lessons have been applied to minimal or artificial enzyme cascades. This article is part of a Special Issue entitled Biodesign for Bioenergetics — the design and engineering of electronic transfer cofactors, proteins and protein networks, edited by Ronald L. Koder and J.L. Ross Anderson.