Endothelial Dysfunction Is Reversible in Helicobacter Pylori-Positive Subjects

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• 作者：Arnon Blum MD^a ;   ; ^b ;   ; ^c ;   ; ^{ABlum@med.miami.edu} ; Snait Tamir PhD^d ; Keren Mualem BSc^c ; Rotem Shelly Ben-Shushan MSc^d ; Lital Keinan-Boker MD ; PhD^e ; Maya Paritsky MD^b
• 关键词：Cardiovascular prevention ; Endothelial function ; Helicobacter pylori
• 刊名：The American Journal of Medicine
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：124
• 期：12
• 页码：1171-1174
• 全文大小：207 K

文摘

Background

Studies have shown an association between Helicobacter pylori (HP) infection and atherosclerosis. Although epidemiological studies have suggested an association between HP infection and atherosclerosis, the issue is still controversial. It is not clear whether HP eradication will reverse endothelial damage and prevent cardiovascular events.

Methods

Thirty-one dyspeptic subjects (16 men, 15 women; 50.8 ¡À 16.7 years) were diagnosed as HP positive using histopathological evaluation. Eleven dyspeptic subjects (5 men, 6 women; 55.4 ¡À 9.3 years) were negative to HP (controls). Interleukin-6 level and vascular measurements (ankle brachial index and flow-mediated diameter percent change) were done twice: on entry and 3 months afterwards. HP-positive subjects were treated with the triple therapy.

Results

Thirty-one HP-positive subjects (50.8 ¡À 16.7 years, 16 men, weight 79.6 ¡À 14.8 kg, height 1.70 ¡À 0.1 m, body mass index [BMI] 27.5 ¡À 4.4, waist circumference 97.6 ¡À 16.7 cm) were treated accordingly. There were 11 HP-negative subjects (controls) (55.4 ¡À 9.3 years, 5 men, weight 83.4 ¡À 16.8 kg, height 1.68 ¡À 0.1 m, BMI 29.6 ¡À 6.1, waist circumference 104.4 ¡À 13.7 cm). No difference in age (P = .27), weight (P = .51), height (P = .50), BMI (P = .30), or waist circumference (P = .20) was observed. HP-positive subjects had severe endothelial dysfunction (?.26 ¡À 8.4 % ) that improved after treatment (8.4 ¡À 9.0 % ) (P = .001). HP-negative subjects had endothelial dysfunction (1.9 ¡À 9.7 % ) that was not improved (5.6 ¡À 8.3 % ) (P = .41). Interleukin-6 levels in serum were not elevated in HP-positive subjects before or after HP eradication (8.4 ¡À 17.5 vs 13.5 ¡À 30.7 pg/mL; P = .45).

Conclusions

The novel finding of our study was that HP eradication can improve endothelial dysfunction.