Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice
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- 作者：Matí ; as Alvarez-Saavedra1 ; 2 ; 7 ; 8 ; 9 ; matias.alvarez-saavedra@nyumc.org" class="auth_mail" title="E-mail the corresponding author ; Yves De Repentigny1 ; Doo Yang3 ; 4 ; Ryan W. O&rsquo ; Meara1 ; 2 ; Keqin Yan1 ; Lukas E. Hashem1 ; 2 ; Lemuel Racacho3 ; 5 ; Ilya Ioshikhes3 ; 4 ; Dennis E. Bulman5 ; 6 ; Robin J. Parks1 ; 3 ; Rashmi Kothary1 ; 2 ; David J. Picketts1 ; 2 ; 3 ; dpicketts@ohri.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Snf2h ; Smarca5 ; VGF ; myelin ; oligodendrocyte ; Purkinje ; cerebellum ; running ; exercise ; remyelination
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：17
- 期：3
- 页码：862-875
- 全文大小：7830 K
文摘
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Running promotes the survival of mice with cerebellar ataxia following Snf2h inactivation
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Running ataxic mice show enhanced oligodendrogenesis and de novo myelination
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Comparative RNA-seq studies identify VGF as a contributor to brain repair
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VGF overexpression improves ataxic phenotype in mice without exercise