Transcorneal electrical stimulation promotes survival of retinal ganglion cells after optic nerve transection in rats accompanied by reduced microglial activation and TNF-α expression
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- 作者：Houmin Yina ; 1 ; Houfa Yinb ; c ; 1 ; Wei Zhangd ; Qi Miaob ; c ; Zhenwei Qinb ; c ; Shenchao Guob ; c ; Qiuli Fub ; c ; Jian Mab ; c ; Fang Wub ; c ; Jinfu Yinb ; c ; Yabo Yangb ; c ; Xiaoyun Fangb ; c ; xiaoyunfang@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain-derived neurotrophic factor ; CNTF ; ciliary nerve trophic factor ; FG ; Fluorogold ; FGF-2 ; fibroblast growth factor beta ; GCL ; ganglion cell layer ; GFAP ; glial fibrillary acidic protein ; GS ; glutamine synthetase ; Iba1 ; ionized calcium-binding adaptor molecule 1 ; IGF-1 ; insulin-like growth factor-1 ; IL-1β ; interleukin-1beta ; ONC ; optic nerve crush ; ONT ; optic nerve transection ; RGCs ; retinal ganglion cells ; RP ; retinitis pigmentosa ; TES ; transcorneal electrical stimulation ; TNF-α ; tumor
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：1650
- 期：Complete
- 页码：10-20
- 全文大小：8760 K
文摘
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Microglia are the major source of TNF-α after ONT.
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TES-mediated RGCs protection is accompanied by reduced microglial activation.
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TES promotes RGCs survival accompanied by reduced microglia-derived TNF-α expression.