Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1
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- 作者：Yan-Jie Wanga ; 1 ; Xiao-Long Guoa ; b ; 1 ; Sheng-An Lia ; Yu-Qi Zhaoc ; Zi-Chao Liud ; Wen-Hui Leea ; Yang Xianga ; yang_xiang000@hotmail.com" class="auth_mail ; Yun Zhanga ; zhangy@mail.kiz.ac.cn" class="auth_mail
- 关键词：Prohibitin ; PAR1 ; Activated internalization ; Erk1/2 signaling degradation
- 刊名：Biochimica et Biophysica Acta (BBA)/Molecular Cell Research
- 出版年：July 2014
- 年：2014
- 卷：1843
- 期：7
- 页码：1393-1401
- 全文大小：1361 K
文摘
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PHB is involved the activated internalization of PAR1.
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PHB represses the degradation of PAR1 in endothelial and high invasive cells.
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Erk1/2 phosphorylation duration is related with the activated internalization of PAR1.
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The absence of membrane PHB leads to the highly invasive ability of MDA-MB-231 cells.