TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships
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- 作者：Juan-Juan Sheng ; Jian-Ping Jin ; jjin@med.wayne.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; AMP-activated protein kinase ; cTnI ; cardiac isoform of troponin I ; cTnI-ND ; N-terminal truncated cardiac troponin I ; DA ; distal arthrogryposis ; fsTnI ; fast skeletal muscle isoform of troponin I ; Mst1 ; mammalian sterile 20-like kinase 1 ; O-GlcNAc ; O-linked β-N-acetyl-d-glucosamine ; PKA ; protein kinase A ; PKC ; protein kinase C ; PKD ; protein kinase D ; PKG ; protein kinase G ; ssTnI ; slow skeletal muscle isoform of troponin I ; TnI ; troponin I ; TnT ; troponin T ; TnC ; troponin C
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：385-394
- 全文大小：1128 K
文摘
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Higher vertebrate genomes contain three troponin I genes, TNNI1, TNNI2 and TNNI3.
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The muscle fiber type-specific troponin I isoforms are evolutionarily diverged.
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Each of the isoform genes is conserved across species.
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The N-terminal extension of cardiac troponin I is an adult heart-specific regulator.
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Mutations of troponin I cause myopathies.