Synthesis and insecticidal evaluation of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one derivatives
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- 作者：Xuan-Qi Liua ; Ya-Qin Liua ; Xu-Sheng Shaoa ; Zhi-Ping Xua ; Xiao-Yong Xua ; Zhong Lia ; b ; lizhong@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neonicotinoids ; Tetrahydroimidazo[1 ; 2-a]pyridin-5(1H)-one ; Configuration ; Insecticidal activity
- 刊名：Chinese Chemical Letters
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：27
- 期：1
- 页码：7-10
- 全文大小：449 K
文摘
A series of novel tetrahydroimidazo[1,2-a]pyridine-5(1H)-one derivatives containing a electronegative pharmacophore (
CNO2) were synthesized via practical aza-ene reaction and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. Preliminary bioassays showed that some of the target compounds exhibited good insecticidal activity against brown planthopper (Nilaparvata lugens) and cowpea aphids (Aphis craccivora) at 500 mg L−1. Among them, compound 11h was active against brown planthopper at 100 mg L−1. The insecticidal activities varied significantly depending on the types and patterns of the substituents, which provided guidance for further investigation on structure modifications.
CNO2) were synthesized via practical aza-ene reaction and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. Preliminary bioassays showed that some of the target compounds exhibited good insecticidal activity against brown planthopper (Nilaparvata lugens) and cowpea aphids (Aphis craccivora) at 500 mg L−1. Among them, compound 11h was active against brown planthopper at 100 mg L−1. The insecticidal activities varied significantly depending on the types and patterns of the substituents, which provided guidance for further investigation on structure modifications.