Association of vitamin D receptor gene polymorphisms with response to peginterferon plus ribavirin in Asian patients with chronic hepatitis C

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• 作者：Chao-Hung Hung ; ^{chh4366@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author} ; Tsung-Hui Hu ; Sheng-Nan Lu ; Chien-Hung Chen ; Jing-Houng Wang ; Chuan-Mo Lee
• 关键词：Asia ; hepatitis C ; interferon ; sustained virological response ; vitamin D receptor
• 刊名：Journal of the Formosan Medical Association
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：115
• 期：4
• 页码：278-283
• 全文大小：440 K

文摘

Recent studies have shown that serum vitamin D deficiency is a negative predictor of response to peginterferon plus ribavirin therapy for Caucasian patients with chronic hepatitis C (CHC). Whether vitamin D receptor (VDR) gene polymorphisms associate with antiviral response in Asian CHC patients remains unclear.

Methods

We recruited 139 Asian patients with CHC genotype-1 who achieved 80/80/80 adherence of response-guided peginterferon plus ribavirin therapy. BsmI rs1544410, ApaI rs7975232, and TaqI rs731236 were genotyped and related to clinical and virological features and to treatment outcome.

Results

Patients carrying bAt [CCA] haplotype (p = 0.033), ApaI CC genotype (p = 0.033), and TaqI AA genotype (p = 0.037) had a higher HCV load as compared to those with other haplotypes, ApaI CA/AA genotype and TaqI AG genotype, respectively. A sustained virological response (SVR) was achieved in 74 (53%) of the patients. Polymorphisms in VDR gene did not correlate with rapid virological response and SVR achievement. Stepwise logistic regression analysis showed that rs12979860 CC type [odds ratio (OR): 5.56, p = 0.007], platelet counts ≥ 15 × 10¹⁰/L (OR: 4.80, p = 0.001), and rapid virological response achievement (OR: 8.36, p < 0.001) were independent factors of SVR.

Conclusion

Despite their associations with high hepatitis C virus load, VDR gene polymorphisms are not related to the response to peginterferon plus ribavirin therapy in Asian CHC patients.