Sinoscrewtine, an alkaloid with novel skeleton from the roots of Sinomenium acutum

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• 作者：Xiao-Ling Wang^a ; ^{xlwangwang@163.com} ; Bing-Rui Liu^b ; Chien-Kuang Chen^d ; Guo-Wei Qin^c ; Shoei-Sheng Lee^d
• 关键词：Sinoscrewtine ; Injurious effects against H2O2/A¦Â25&ndash ; 35 induced oxidative injury ; DPPH radical scavenging activity ; Sinomenium acutum
• 刊名：Fitoterapia
• 出版年：2013
• 出版时间：January, 2013
• 年：2013
• 卷：84
• 期：Complete
• 页码：54-57
• 全文大小：320 K

文摘

An alkaloid with novel skeleton, sinoscrewtine (1), has been isolated from the roots of Sinomenium acutum. Its structure was established by spectral analysis and X-ray crystallographic study, and its possible biosynthetic pathway was delivered. In vitro experiments, 1 showed weak injurious effects against H₂O₂/A¦Â_25-35 induced oxidative injury in PC-12 cells and DPPH radical scavenging activity with IC₅₀ of 32.6 ¦ÌM.