Gelatinases promote calcification of vascular smooth muscle cells by up-regulating bone morphogenetic protein-2
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- 作者：Yong-Gang Zhao zyg307@126.com" class="auth_mail" title="E-mail the corresponding author ; Fan-Xing Meng mfx2143@163.com" class="auth_mail" title="E-mail the corresponding author ; Bing-Wei Li drli715@163.com" class="auth_mail" title="E-mail the corresponding author ; You-Ming Sheng shengbiomed@163.com" class="auth_mail" title="E-mail the corresponding author ; Ming-Ming Liu mingmingliu@imc.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Bing Wang bw20032007@126.com" class="auth_mail" title="E-mail the corresponding author ; Hong-Wei Li lihw66@imc.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Rui-Juan Xiu ; xiurj@imc.pumc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vascular calcification ; Vascular smooth muscle cell ; Matrix metalloproteinase-2 ; Bone morphogenetic protein-2 ; Runt-related transcription factor 2
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：470
- 期：2
- 页码：287-293
- 全文大小：1369 K
文摘
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Gelatinases inhibition reduced calcification of cultured VSMCs.
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Gelatinases inhibition attenuated phenotype transition of cultured VSMCs.
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Gelatinases inhibition reduces calcification of VSMCs by down-regulating BMP-2.
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Gelatinases are potential targets for treatment of vascular calcification.