A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors
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- 作者：Namal C. Warshakoon ; Shengde Wu ; Angelique Boyer ; Richard Kawamoto ; Justin Sheville ; Sean Renock ; Kevin Xu ; Matthew Pokross ; Artem G. Evdokimov ; Richard Walter and Marlene Mekel
- 关键词：HIF-1α ; prolyl hydroxylase inhibitors ; Imidazo[1 ; 2-a]pyridines
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2006
- 出版时间：1 November 2006
- 年：2006
- 卷：16
- 期：21
- 页码：5598-5601
- 全文大小：279 K
文摘
Utilizing modeling information from a recently resolved structure of human HIF-1α prolyl hydroxylase (EGLN1) and structure-based design, a novel series of imidazo[1,2-a]pyridine derivatives was prepared. The activity of these compounds was determined in a human EGLN1 assay and a limited SAR was developed.