Bradykinin promoted migration and invasion of HepG2 cells through TRPM7 and MMP2.
The effect of Bradykinin on NMHC-IIA Ser-1943 was similar to EGF's.
Ser-1943 could be an overlooked phosphorylation site on NMHC-IIA for TRPM7.
Both NM-IIA and calpains were important for migrating cancer cells.
Src regulated the invadopodia formation and MMP2 secretion of HepG2 cells.