Energy cost of activity and exercise in children and adolescents with cystic fibrosis

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• 作者：Mark R. Johnson ; Thomas W. Ferkol and Ross W. Shepherd
• 关键词：Cystic fibrosis ; Energy expenditure ; Cardiopulmonary exercise testing
• 刊名：Journal of Cystic Fibrosis
• 出版年：2006
• 出版时间：January 2006
• 年：2006
• 卷：5
• 期：1
• 页码：53-58
• 全文大小：107 K

文摘

In cystic fibrosis (CF), perturbations of total daily energy expenditure (TDEE) may be a major determinant of altered nutrition and growth. Measurement of TDEE is problematic, though the flex-heart rate method (FHRM) provides a close estimation of TDEE, as compared to the cost-prohibitive, gold standard, the double-labeled water method, and permits estimates of the energy cost of daily activities (ECA) above resting energy expenditure (REE). We hypothesize that alterations in ECA affects TDEE in CF.

Purpose

To measure components of TDEE in adolescents with CF and normal lung function compared with controls, and to determine whether ECA can be improved by diet and exercise.

Methods

Clinically stable CF subjects (aged 9–13, n = 12) and age- and gender-matched controls (n = 13) had repeated measurements of TDEE by FHRM, REE, and maximal cardiopulmonary exercise testing (CPET) during a 6-week exercise and diet program.

Results

While the mean REE was similar in both groups, ECA was significantly lower in CF adolescents as compared to controls (p = 0.02). During CPET, maximal exercise in CF was characterized by hyperventilation, which was unrelated to ventilation–perfusion mismatching. There were no changes in REE after dietary intervention.

Conclusion

ECA in CF adolescents with normal lung function is lower when compared to healthy controls. These findings support the hypothesis that clinically stable patients with CF have inefficient energy metabolism or alternatively conserve energy during activities of daily living.