An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens
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- 作者：Nicole Robbins1 ; Michaela Spitzer1 ; Tennison Yu1 ; Robert P. Cerone2 ; Anna K. Averette5 ; Yong-Sun Bahn6 ; Joseph Heitman5 ; Donald C. Sheppard3 ; Mike Tyers4 ; Gerard D. Wright1 ; wrightge@mcmaster.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：17 November 2015
- 年：2015
- 卷：13
- 期：7
- 页码：1481-1492
- 全文大小：3908 K
文摘
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The Antifungal Combination Matrix reports 1,550 antifungal drug combinations
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ACM combinations act against fungal pathogens including azole-resistant C. albicans
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Clofazimine potentiates antifungals in diverse fungi by targeting membrane function
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Clofazimine potentiates caspofungin in an invertebrate model of fungal pathogenesis