Etiology of Sudden Death in Sports: Insights From a United Kingdom Regional Registry

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• 作者：Gherardo Finocchiaro ; MD^a ; Michael Papadakis ; MBBS ; MD^a ; Jan-Lukas Robertus ; MD^b ; Harshil Dhutia ; MBBS^a ; Alexandros Klavdios Steriotis ; MD ; PhD^a ; Maite Tome ; MD ; PhD^a ; Greg Mellor ; MBChB^a ; Ahmed Merghani ; MBBS^a ; Aneil Malhotra ; MBBChir^a ; Elijah Behr ; MBBS ; MD^a ; Sanjay Sharma ; MBChB ; MD^a ; ^{sasharma@sgul.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Mary N. Sheppard ; MBBCh ; BAO ; MD^b
• 关键词：arrhythmogenic right ventricular cardiomyopathy ; athletes ; sudden death
• 刊名：Journal of the American College of Cardiology
• 出版年：2016
• 出版时间：10 May 2016
• 年：2016
• 卷：67
• 期：18
• 页码：2108-2115
• 全文大小：919 K

文摘

Accurate knowledge of causes of sudden cardiac death (SCD) in athletes and its precipitating factors is necessary to establish preventative strategies.

Objectives

This study investigated causes of SCD and their association with intensive physical activity in a large cohort of athletes.

Methods

Between 1994 and 2014, 357 consecutive cases of athletes who died suddenly (mean 29 ± 11 years of age, 92% males, 76% Caucasian, 69% competitive) were referred to our cardiac pathology center. All subjects underwent detailed post-mortem evaluation, including histological analysis by an expert cardiac pathologist. Clinical information was obtained from referring coroners.

Results

Sudden arrhythmic death syndrome (SADS) was the most prevalent cause of death (n = 149 [42%]). Myocardial disease was detected in 40% of cases, including idiopathic left ventricular hypertrophy (LVH) and/or fibrosis (n = 59, 16%); arrhythmogenic right ventricular cardiomyopathy (ARVC) (13%); and hypertrophic cardiomyopathy (HCM) (6%). Coronary artery anomalies occurred in 5% of cases. SADS and coronary artery anomalies affected predominantly young athletes (≤ 35 years of age), whereas myocardial disease was more common in older individuals. SCD during intense exertion occurred in 61% of cases; ARVC and left ventricular fibrosis most strongly predicted SCD during exertion.

Conclusions

Conditions predisposing to SCD in sports demonstrate a significant age predilection. The strong association of ARVC and left ventricular fibrosis with exercise-induced SCD reinforces the need for early detection and abstinence from intense exercise. However, almost 40% of athletes die at rest, highlighting the need for complementary preventive strategies.