A convenient and scaleable procedure for removing the Fmoc group in solution
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- 作者：Sheppeck II ; James E. ; Kar ; Heidi ; Hong ; Hui
- 关键词：protecting groups ; thiols ; polymer support ; supported reagents/reaction
- 刊名：Tetrahedron Letters
- 出版年：2000
- 出版时间：July 8, 2000
- 年：2000
- 卷：41
- 期：28
- 页码：5329-5333
- 全文大小：162 K
文摘
An improved and simple reagent system was developed to facilitate solution-phase deprotection of Fmoc-protected amines. Catalytic DBU in the presence of an aliphatic or polymer-supported thiol rapidly removed the Fmoc group to provide the amine free base in excellent yields and purity on multi-gram scale.