Prenatal dichlorodiphenyldichloroethylene (DDE) exposure and child growth during the first year of life

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• 作者：Sheyla Garced^a ; ^{sgarced@gmail.com} ; Luisa Torres-S&aacute ; nchez^b ; ^{ltorress@insp.mx} ; Mariano E. Cebri&aacute ; n^c ; ^{mcebrian@cinvestav.mx} ; Luz Claudio^a ; ^{luz.claudio@mssm.edu} ; Lizbeth Ló ; pez-Carrillo^b ; ^{lizbeth@insp.mx}
• 关键词：p ; p&prime ; -dichlorodiphenyldichloroethene (DDE) ; Child anthropometric measurements ; Organochlorines ; Z-scores ; Mexico
• 刊名：Environmental Research
• 出版年：2012
• 出版时间：February, 2012
• 年：2012
• 卷：113
• 期：Complete
• 页码：58-62
• 全文大小：148 K

文摘

Background

Due to its long-term persistence in the environment and its ability to cross the placental barrier, prenatal p,p?dichlorodiphenyldichloroethene (DDE) exposure continues to be a public health concern. This study aimed to evaluate the association between prenatal DDE exposure and child growth, at birth and during the first year of life.

Methods

253 pregnant women were recruited between January 2001 and June 2005 in a prospective cohort in Morelos, Mexico. Serum levels of DDE were measured during each trimester of pregnancy by gas chromatography with an electron capture detector. Using the generalized mixed-effects models, the association between DDE and child growth parameters (weight-for-age, length-for-age, weight-for-length, BMI-for-age and head circumference-for-age m>Zm>-scores) from birth to 1 year of age was assessed. Maternal dietary intake was considered as covariable among others.

Results

DDE levels were 6.3¡À2.8 ng/mL (first trimester), 6.6¡À2.9 ng/mL (second trimester), and 7.6¡À2.9 ng/mL (third trimester). After adjusting for potential confounder variables, no significant associations were observed with prenatal DDE exposure and each of the selected parameters.

Conclusions

Our results show no evidence of an association between prenatal DDE exposure and child growth during the first year of life.