Efficacy of hepatitis B vaccine boosters among neonatally vaccinated university freshmen in Taiwan

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• 作者：Fu-Hsiung Su¹ ; ² ; Fang-Yeh Chu³ ; Chi-Hui Bai¹ ; Yu-Shiang Lin¹ ; ³ ; Yu-Mei Hsueh¹ ; Fung-Chang Sung⁴ ; Chih-Ching Yeh¹ ; ⁴ ; ^{ccyeh@tmu.edu.tw}
• 关键词：HBV ; hepatitis B virus ; HBsAg ; hepatitis B surface antigen ; anti-HBs ; antibodies to hepatitis B surface antigen ; anti-HBc ; antibodies to hepatitis B core antigen ; ALT ; alanine aminotransferase ; GMT ; geometric mean titer ; CI ; confidence interval
• 刊名：Journal of Hepatology
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：58
• 期：4
• 页码：684-689
• 全文大小：498 K

文摘

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Background & Aims

Long-term protection against hepatitis B virus (HBV) after vaccination remains widely debated. We evaluated the efficacy of a modified 3-dose booster protocol in neonatally vaccinated university students in Taiwan.

Methods

Changes in the levels of antibodies to the hepatitis B surface antigen (anti-HBs) were examined in 250 university students over a 3-year period. Group A (n = 39) lacked seroprotective levels of anti-HBs, and declined to receive a booster dose of the HBV vaccine. Group B (n = 128) lacked seroprotective levels of anti-HBs, and received booster doses of the HBV vaccine according to a modified 3-dose booster protocol. Group C (n = 83) possessed seroprotective levels of anti-HBs, and did not receive a booster dose.

Results

The levels of seroprotective anti-HBs increased in 12.8 % of Group A and 14.5 % of Group C, suggesting that our entire cohort had experienced booster effects from natural HBV exposure. However, no new HBV infections were observed, and 53.9 % of Group B maintained protective levels of anti-HBs during the follow-up period.

Conclusions

The use of the modified 3-dose booster protocol induced significant long-term increases in the titer of anti-HBs in over 50 % of the neonatally vaccinated participants with previously non-protective titers. However, in the absence of a vaccine booster, some neonatally vaccinated people with low anti-HBs titers may nonetheless produce anamnestic responses to HBV upon exposure, suggesting that protection from neonatal vaccination may persist, despite low titers of anti-HBs.