CLOCK modulates survival and acute lung injury in mice with polymicrobial sepsis
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- 作者：Chao-Yung Wanga ; 1 ; cwang@ocean.ag" class="auth_mail" title="E-mail the corresponding author ; Ming-Jer Hsieha ; 1 ; I-Chang Hsieha ; Shian-Sen Shieb ; Ming-Yun Hoa ; Jih-Kai Yeha ; Ming-Lung Tsaia ; Chia-Hung Yanga ; Kuo-Chun Hunga ; Chun-Chieh Wanga ; Ming-Shien Wena ; wenms123@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Circadian rhythm ; Sepsis ; Lung injury ; Inhibin ; Polymicrobial infection
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：16 September 2016
- 年：2016
- 卷：478
- 期：2
- 页码：935-941
- 全文大小：933 K
文摘
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CLOCK-deficient mice have better survival than wild-type mice after sepsis.
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Inflammatory cytokine production is attenuated in CLOCK-deficient mice.
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CLOCK–inhibin signaling is associated with improved acute lung by sepsis.