Immunization with BLS-Stx2B chimera totally protects dams from early pregnancy loss induced by Shiga toxin type 2 (Stx2) and confers anti-Stx2 immunity to the offspring
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- 作者：Flavia Sacerdotia ; Marí ; a P. Mejí ; asb ; Andrea C. Bruballab ; Romina Soledad Alvareza ; Marí ; a M. Amarala ; Marina S. Palermob ; Cristina Ibarraa ; ibarra@fmed.uba.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; BLS ; lumazine synthase from Brucella spp. ; CD50 ; 50% cytotoxic dose ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium ; FBS ; fetal bovine serum ; gd ; gestation day ; Gb3 ; globotriaosylceramide ; HUS ; Hemolytic Uremic Syndrome ; i.p. ; intraperitoneally ; IgG ; immunoglobulin G ; IgA ; immunoglobulin A ; LPS ; lipopolysaccharide ; PBS ; phosphate-buffered saline ; Stx ; Shiga toxin ; Stx1 ; Shiga toxin type 1 ; Stx2 ; Shiga toxin type 2 ; Stx2B ; B subunit of Stx2 ; Stx2A ; A subunit of
- 刊名：Vaccine
- 出版年：2016
- 出版时间：7 September 2016
- 年：2016
- 卷：34
- 期：39
- 页码：4732-4737
- 全文大小：1018 K
文摘
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An in vivo study concerning anti-Shiga toxin type 2 (Stx2) immunity was perfomed.
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Active immunization was induced in rats against Stx2 using BLS-Stx2B as immunogen.
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Circulating anti Stx2B antibodies prevented early pregnancy loss mediated by Stx2.
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Pups breastfed by immunized dams were protected from a lethal dose of Shiga toxin.