High serum level of neopterin is a risk factor of patients with heart failure

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• 作者：Toshiki Sasaki ; Yasuchika Takeishi ; Satoshi Suzuki ; Takeshi Niizeki ; Tatsuro Kitahara ; Shigehiko Katoh ; Mitsunori Ishino ; Tetsuro Shishido ; Tetsu Watanabe ; Isao Kubota
• 关键词：Heart failure ; Biomarker ; Prognosis ; Oxidative stress
• 刊名：International Journal of Cardiology
• 出版年：2010
• 出版时间：19 November 2010
• 年：2010
• 卷：145
• 期：2
• 页码：318
• 全文大小：66 K

文摘

Serum neopterin concentration was measured in 198 patients with chronic heart failure (CHF) and 62 control subjects by ELISA. Patients were prospectively followed during a median follow-up period of 745 days with end points of cardiac death or re-hospitalization due to progressive heart failure. Serum concentration of neopterin increased with advancing New York Heart Association (NYHA) functional class (P < 0.001). High neopterin group had a significantly higher incidence of cardiac events than low neopterin group (P < 0.0001). In the multivariate Cox analysis, serum neopterin concentration was an independent risk factor for cardiac events (hazard ratio 1.70, 95 % CI 1.16–2.50, P = 0.0068). Serum neopterin concentration is a novel prognostic marker for CHF.