The role of macrophage transcription factor MafB in atherosclerotic plaque stability
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- 作者：Hiromasa Hasegawa ; Tetsu Watanabe ; tewatana@med.id.yamagata-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shigehiko Kato ; Taku Toshima ; Miyuki Yokoyama ; Yasuko Aida ; Michiko Nishiwaki ; Shinpei Kadowaki ; Taro Narumi ; Yuki Honda ; Yoichiro Otaki ; Shintaro Honda ; Netsu Shunsuke ; Akira Funayama ; Satoshi Nishiyama ; Hiroki Takahashi ; Takanori Arimoto ; Tetsuro Shishido ; Takuya Miyamoto ; Shuichi Abe ; Yoko Shibata ; Isao Kubota
- 关键词：MafB ; Macrophage ; Plaque stability ; Apoptosis
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：250
- 期：Complete
- 页码：133-143
- 全文大小：2071 K
文摘
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Macrophage-specific MafB inhibition deteriorated atherosclerotic plaque stability.
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MafB inhibition did not affect atherosclerotic lesion area.
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MafB inhibition was susceptible to macrophage apoptosis induced by oxidative stress.
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MafB inhibition did not affect macrophage infiltration and efferocytosis.
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MafB inhibition augmented expression of MMP-9 and inflammatory mediators.