Accelerated telomere length shortening in granulocytes: A diagnostic marker for myeloproliferative diseases

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• 作者：Terasaki ; Yasushi ; Okumura ; Hirokazu ; Ohtake ; Shigeki ; Nakao ; Shinji
• 刊名：Experimental Hematology
• 出版年：2002
• 出版时间：December, 2002
• 年：2002
• 卷：30
• 期：12
• 页码：1399-1404
• 全文大小：180 K

文摘

The telomere in mature myeloid cells derived from abnormal progenitor cells of myeloproliferative diseases (MPDs) may shorten more rapidly than that in T lymphocytes, which are considered to be derived from normal clones. To test this hypothesis, we measured telomere lengths in granulocytes and T lymphocytes from patients with MPDs and compared them with those from normal individuals.