Cost-effectiveness of quadrivalent human papillomavirus (HPV) vaccination in Mexico: A transmission dynamic model-based evaluation

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• 作者：Ralph P. Insinga ; Erik J. Dasbach ; Elamin H. Elbasha ; Andrea Puig ; Luz Myriam Reynales-Shigematsu
• 关键词：Human papillomavirus ; Vaccine ; Cost-effectiveness analysis
• 刊名：Vaccine
• 出版年：2007
• 出版时间：21 December 2007
• 年：2007
• 卷：26
• 期：1
• 页码：128-139
• 全文大小：712 K

文摘

We examined the potential health outcomes and cost-effectiveness of quadrivalent human papillomavirus (HPV) 6/11/16/18 vaccination strategies in the Mexican population using a multi-HPV type dynamic transmission model. Assuming similar cervical screening practices, with or without vaccination, we examined the incremental cost-effectiveness of vaccination strategies for 12 year-old females, with or without male vaccination, and temporary age 12–24 catch-up vaccination for females or both sexes. The most effective strategy therein was vaccination of 12-year-olds, plus a temporary 12–24-year-old catch-up program covering both sexes; whereby HPV 6/11/16/18-related cervical cancer, high-grade cervical precancer, and genital wart incidence was reduced by 84–98 % during year 50 following vaccine introduction. Incremental cost-effectiveness ratios in the primary analyses ranged from $3000 (U.S.) per quality-adjusted life year (QALY) gained for female vaccination strategies to $16000/QALY for adding male vaccination with catch-up.