- 作者：Eiji Kirino ; Yayoi Hayakawa ; Mayuko Fukuta ; Rie Inami ; Reiichi Inoue ; Shigeru Aoki ; Heii Arai
- 刊名：Clinical Neurophysiology
- 出版年：2013
- 出版时间：August, 2013
- 年：2013
- 卷：124
- 期：8
- 页码：e25
- 全文大小：37 K
Methods: We recorded EEG during event-related functional MRI (fMRI) followed by diffusion tensor imaging (DTI) in 14 healthy volunteers and 12 schizophrenic patients. The fMRI data was analyzed on SPM08 and blood oxygenation level-dependent signals (BOLD) signal changes were calculated in region of interest analysis using MarsBaR software. In DTI analysis, the areas significantly deteriorated in patients compared to controls were detected with tract-based spatial statistics. Fractional anisotropy (FA) in white matter fibers related to each area was compared between groups using tract-specific analysis. The clinical manifestation in the patients was evaluated using the Positive and Negative Syndrome Scale (PANSS).
Results: The correlation analysis on SPM revealed significant correlation between FA of the right uncinate fasciculus and BOLD activity in the left Insula. BOLD activity of the right anterior cingulate, the right corpus callosum and right insula significantly correlated with PANSS scores.
Conclusion: The dysfunction of Insula, the uncinate fasciculus and the corpus callosum, as well as the temporal lobe and the anterior cingulate gyrus, may specifically contribute to MMN aberration of schizophrenic patients and clinical manifestations reflecting their impaired MMN generation.