The isolation and synthesis of two novel N-acetyl glucosamine derivatives from Dictyostelium cellular slime molds which exhibit neurite outgrowth activity
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- 作者：Kikuchi ; Haruhisa ; Komiya ; Jun ; Saito ; Yoshinori ; Sekiya ; Jun-ichi ; Honma ; Shigeyoshi ; Nakahata ; Norimichi ; et. al.
- 关键词：cellular slime molds ; amino sugars ; differentiation ; PC-12 cell
- 刊名：Tetrahedron Letters
- 出版年：2002
- 出版时间：February 18, 2002
- 年：2002
- 卷：43
- 期：8
- 页码：1477-1480
- 全文大小：104 K
文摘
To clarify the diversity of secondary metabolites of Dictyostelium cellular slime molds and explore any biologically active substances which they may hold, constituents of two species were investigated. From a methanol extract of their fruit bodies, two novel acylated amino sugars were isolated, dictyoglucosamine A (1) from D. purpureum and dictyoglucosamine B (2) from D. discoideum. For further analysis, these compounds were then synthesized from N-acetyl-d-glucosamine. Biological evaluation of 1 and 2 showed they induce neuronal differentiation of rat pheochromocytoma (PC-12) cells.